Imidacloprid insecticide exposure induces stress and disrupts glucose homeostasis in male rats

被引：56
作者：
Khalil, Samah R. [1 ]
Awad, Ashraf [2 ]
Mohammed, Hesham H. [3 ]
Nassan, Mohamed Abdo [4 ]
机构：
[1] Zagazig Univ, Fac Vet Med, Dept Forens Med & Toxicol, Zagazig 44511, Egypt
[2] Zagazig Univ, Fac Vet Med, Anim Wealth Dev Dept, Zagazig, Egypt
[3] Zagazig Univ, Dept Vet Publ Hlth, Fac Vet Med, Zagazig, Egypt
[4] Zagazig Univ, Dept Pathol, Fac Vet Med, Zagazig, Egypt
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2017年 / 55卷
关键词：
Forced swim test; Glucose transporter; Imidacloprid; Neonicotinoid; Open field test; NICOTINIC ACETYLCHOLINE-RECEPTOR; GLUT2; GENE-EXPRESSION; TAIL SUSPENSION TEST; INSULIN-RESISTANCE; OXIDATIVE STRESS; OPEN-FIELD; IN-VITRO; NEONICOTINOID INSECTICIDES; INDUCED NEUROTOXICITY; SELECTIVE TOXICITY;
D O I：
10.1016/j.etap.2017.08.017
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
In the present study, we evaluated the stress response in adult rats who were administered imidacloprid (IMI) orally in two doses (0.5 and 1.0 mg/kg bw for 60 days). It led to an alteration in the levels of cortisone and catecholamines and induced behavioral deficits, particularly in the animals exposed to the dose of 1.0 mg/kg. IMI was further analyzed for the effect on glucose homeostasis in developing and adult rats at a dose of 1.0 mg/kg bw where it elicited a hyperglycemic effect. Moreover, we observed an alteration in the mRNA levels of glucose transporters. Histopathological and immunohistochemical data displayed structural perturbations in pancreatic tissue with a decline in the expression of insulin and GLUT4, particularly in the developing rats. Collectively, IMI treatment resulted in stress represented by behavioral and biochemical changes, particularly at a dose of 1.0 mg/kg bw. Moreover, IMI perturbed the glucose regulation through hyperglycemic activity in both developing and adult rats, an observation clearly evident in the developing rats.
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收藏
页码：165 / 174
页数：10
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