Keratin and filaggrin expression in keratoacanthoma

被引：15

作者：

Ito, Yoshiyuki ^{[1
]}

Kurokawa, Ichiro ^{[1
]}

Nishimura, Keisuke ^{[1
]}

Hakamada, Arata ^{[1
]}

Isoda, Ken-ichi ^{[1
]}

Yamanaka, Kei-ichi ^{[1
]}

Tsubura, Airo ^{[2
]}

Mizutanit, Hitoshi ^{[1
]}

机构：

[1] Mie Univ, Grad Sch Med, Dept Dermatol, Tsu, Mie 5148507, Japan

[2] Kansai Med Univ, Dept Pathol, Kansai, Japan

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2008年 / 22卷 / 03期

关键词：

epidermal lip; keratin; keratoacanthoma;

D O I：

10.1111/j.1468-3083.2007.02440.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

To clarify the histogenesis of keratoacanthoma, we studied keratin (K) expression in keratoacanthoma (KA) using 10 different anti-keratin antibodies against K1, K7, K8, K10, K14, K15, K16, K17, K18 and K19 and anti-filaggrin (filament aggregating protein) antibody. In the centre of KA, K1 and K10 expressions were declined, and K 14 and K16 were detected in the tumour cells, suggesting differentiation towards the outer root sheath beneath the orifice of the sebaceous duct. These results suggest that KA differentiates towards the outer root sheath beneath the opening of the sebaceous duct.

引用

页码：353 / 355

页数：3

共 13 条

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