The glomerular transcriptome and a predicted protein-protein interaction network

被引：33

作者：

He, Liqun ^{[2
]}

Sun, Ying ^{[2
]}

Takemoto, Minoru ^{[2
]}

Norlin, Jenny ^{[2
]}

Tryggvason, Karl ^{[2
]}

Samuelsson, Tore ^{[3
]}

Betsholtz, Christer ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Med, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Med Biochem & Biophys, Div Matrix Biol, SE-17177 Stockholm, Sweden

[3] Univ Gothenburg, Dept Med Biochem, Gothenburg, Sweden

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 19卷 / 02期

关键词：

CONGENITAL NEPHROTIC SYNDROME; NAIL-PATELLA SYNDROME; MICE LACKING; GENE-EXPRESSION; SLIT DIAPHRAGM; PERINATAL LETHALITY; ALPORT SYNDROME; HUMAN KIDNEY; MUTANT MICE; NEPHRIN;

D O I：

10.1681/ASN.2007050588

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To increase our understanding of the molecular composition of the kidney glomerulus, we performed a meta-analysis of available glomerular transcriptional profiles made from mouse and man using five different methodologies. We generated a combined catalogue of glomerulus-enriched genes that emerged from these different sources and then used this to construct a predicted protein-protein interaction network in the glomerulus (GlomNet). The combined glomerulus-enriched gene catalogue provides the most comprehensive picture of the molecular composition of the glomerulus currently available, and GlomNet contributes an integrative systems biology approach to the understanding of glomerular signaling networks that operate during development, function, and disease.

引用

页码：260 / 268

页数：9

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