Upstream of ikaros

被引：17

作者：

Liberg, D

Smale, ST

Merkenschlager, M

机构：

[1] Hammersmith Hosp, Imperial Coll, Sch Med, Lymphocyte Dev Grp,MRC,Clin Sci Ctr, London W12 0NN, England

[2] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 11期

关键词：

D O I：

10.1016/j.it.2003.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Haematopoiesis - the process by which pluripotent haematopoietic stem cells choose to become lymphocytes, myeloid cells, red blood cells or platelets - has long been a useful model to study cellular commitment and differentiation. Each cell type is defined by lineage-specific patterns of gene expression. The DNA binding protein Ikaros is an important regulator of haematopoiesis and recent work promises to shed light on how Ikaros itself is regulated.

引用

收藏

页码：567 / 570

页数：4

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