Biocompatible Hydrogel Nanocomposite with Covalently Embedded Silver Nanoparticles

被引：104

作者：

Garcia-Astrain, Clara ^{[1
]}

Chen, Cheng ^{[2
]}

Buron, Maria ^{[3
]}

Palomares, Teodoro ^{[3
]}

Eceiza, Arantxa ^{[1
]}

Fruk, Ljiljana ^{[2
]}

Corcuera, M. Angeles ^{[1
]}

Gabilondo, Nagore ^{[1
]}

机构：

[1] Univ Basque Country, Polytech Sch, Dept Chem & Environm Engn, Mat Technol Grp, San Sebastian 20018, Spain

[2] KIT, DGF Ctr Funct Nanostruct, D-76131 Karlsruhe, Germany

[3] Univ Basque Country, Fac Med & Dent, Leioa 48940, Spain

来源：

BIOMACROMOLECULES | 2015年 / 16卷 / 04期

关键词：

ANTITUMOR DRUG-DELIVERY; ALDER CLICK CHEMISTRY; IN-SITU REDUCTION; GELATIN HYDROGELS; CROSS-LINKING; OXIDE NANOPARTICLES; RELEASE; FILMS; POLYMERIZATION; COMPOSITE;

D O I：

10.1021/acs.biomac.5b00101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bionanocomposite materials, combining the properties of biopolymers and nanostructured materials, are attracting interest of the wider scientific community due to their potential application in design of implants, drug delivery systems, and tissue design platforms. Herein, we report on the use of maleimide-coated silver nanoparticles (Ag NPs) as cocross-linkers for the preparation of a bionanocomposite gelatin based hydrogel. Diels-Alder cycloaddition of benzotriazole maleimide (BTM) functionalized Ag NPs and furan containing gelatin in combination with additional amide coupling resulted in stable and biocompatible hybrid nanocomposite. The storage moduli values for the hydrogel are nearly three times higher than that of control hydrogel without NPs indicating a stabilizing role of the covalently bound NPs. Finally, the swelling and drug release properties of the materials as well as the biocompatibility and toxicity tests indicate the biomedical potential of this type of material.

引用

页码：1301 / 1310

页数：10

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