NKG2D ligands in tumor immunity: two sides of a coin

被引：86

作者：

Zhang, Jinyu ^{[1
]}

Basher, Fahmin ^{[1
]}

Wu, Jennifer D. ^{[1
,2
]}

机构：

[1] Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA

[2] Hollings Canc Ctr, Canc Immunol Program, Charleston, SC USA

来源：

FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷

关键词：

NKG2D ligands; cancer; NK cells; T cells; tumor immunity; I-RELATED CHAIN; NATURAL-KILLER-CELLS; T-CELLS; NK CELLS; CUTTING EDGE; DOWN-REGULATION; EXPRESSION; RECEPTOR; MICA; CYTOTOXICITY;

D O I：

10.3389/fimmu.2015.00097

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is expressed on the surface of all human NK, NKT, CD8+ T and subsets of gamma delta(+) T cells. The significance of NKG2D function in tumor immunity has been well demonstrated in experimental animal models. However, the role of human NKG2D ligands in regulating tumor immunity and cancer prognosis had been controversial in the literature. In this review, we summarize the latest advancement, discuss the controversies, and present evidence that membrane-bound and soluble NKG2D ligands oppositely regulate tumor immunity. We also discuss new perspectives of targeting NKG2D ligands for cancer immunotherapy.

引用

页数：7

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