NKG2D ligands in tumor immunity: two sides of a coin

被引：86
作者：
Zhang, Jinyu [1 ]
Basher, Fahmin [1 ]
Wu, Jennifer D. [1 ,2 ]
机构：
[1] Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA
[2] Hollings Canc Ctr, Canc Immunol Program, Charleston, SC USA
来源：
FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷
关键词：
NKG2D ligands; cancer; NK cells; T cells; tumor immunity; I-RELATED CHAIN; NATURAL-KILLER-CELLS; T-CELLS; NK CELLS; CUTTING EDGE; DOWN-REGULATION; EXPRESSION; RECEPTOR; MICA; CYTOTOXICITY;
D O I：
10.3389/fimmu.2015.00097
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is expressed on the surface of all human NK, NKT, CD8+ T and subsets of gamma delta(+) T cells. The significance of NKG2D function in tumor immunity has been well demonstrated in experimental animal models. However, the role of human NKG2D ligands in regulating tumor immunity and cancer prognosis had been controversial in the literature. In this review, we summarize the latest advancement, discuss the controversies, and present evidence that membrane-bound and soluble NKG2D ligands oppositely regulate tumor immunity. We also discuss new perspectives of targeting NKG2D ligands for cancer immunotherapy.
引用
收藏
页数：7
相关论文
共 85 条
[1]   CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions [J].
Allez, Matthieu ;
Tieng, Vannary ;
Nakazawa, Atsushi ;
Treton, Xavier ;
Pacault, Vincent ;
Dulphy, Nicolas ;
Caillat-Zucman, Sophie ;
Paul, Pascale ;
Gornet, Jean-Marc ;
Douay, Corinne ;
Ravet, Sophie ;
Tamouza, Ryad ;
Charron, Dominique ;
Lemann, Marc ;
Mayer, Lloyd ;
Toubert, Antoine .
GASTROENTEROLOGY, 2007, 132 (07) :2346-2358
[2]   Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes [J].
Ashiru, Omodele ;
Boutet, Philippe ;
Fernandez-Messina, Lola ;
Agueera-Gonzalez, Sonia ;
Skepper, Jeremy N. ;
Vales-Gomez, Mar ;
Reyburn, Hugh T. .
CANCER RESEARCH, 2010, 70 (02) :481-489
[3]   Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D [J].
Bacon, L ;
Eagle, RA ;
Meyer, M ;
Easom, N ;
Young, NT ;
Trowsdale, J .
JOURNAL OF IMMUNOLOGY, 2004, 173 (02) :1078-1084
[4]   Secretory pathways generating immunosuppressive NKG2D ligands New targets for therapeutic intervention [J].
Baragano Raneros, Aroa ;
Suarez-Alvarez, Beatriz ;
Lopez-Larrea, Carlos .
ONCOIMMUNOLOGY, 2014, 3 (04)
[5]   Human Uterine NK Cells Interact with Uterine Macrophages via NKG2D upon Stimulation with PAMPs [J].
Basu, Satarupa ;
Eriksson, Mikael ;
Pioli, Patricia A. ;
Conejo-Garcia, Jose ;
Mselle, Teddy F. ;
Yamamoto, Satoshi ;
Wira, Charles R. ;
Sentman, Charles L. .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2009, 61 (01) :52-61
[6]   Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA [J].
Bauer, Stefan ;
Groh, Veronika ;
Wu, Jun ;
Steinle, Alexander ;
Phillips, Joseph H. ;
Lanier, Lewis L. ;
Spies, Thomas .
JOURNAL OF IMMUNOLOGY, 2018, 200 (07) :2231-2233
[7]   CD28 COSTIMULATION CAN PROMOTE T-CELL SURVIVAL BY ENHANCING THE EXPRESSION OF BCL-X(L) [J].
BOISE, LH ;
MINN, AJ ;
NOEL, PJ ;
JUNE, CH ;
ACCAVITTI, MA ;
LINDSTEN, T ;
THOMPSON, CB .
IMMUNITY, 1995, 3 (01) :87-98
[8]   Cutting Edge: The Metalloproteinase ADAM17/TNF-α-Converting Enzyme Regulates Proteolytic Shedding of the MHC Class I-Related Chain B Protein [J].
Boutet, Philippe ;
Agura-Gonzalez, Sonia ;
Atkinson, Susan ;
Pennington, Caroline J. ;
Edwards, Dylan R. ;
Murphy, Gillian ;
Reyburn, Hugh T. ;
Vales-Gomez, Mar .
JOURNAL OF IMMUNOLOGY, 2009, 182 (01) :49-53
[9]   IFN-Dependent down-regulation of the NKG2D ligand H60 on tumors [J].
Bui, JD ;
Carayannopoulos, LN ;
Lanier, LL ;
Yokoyama, WM ;
Schreiber, RD .
JOURNAL OF IMMUNOLOGY, 2006, 176 (02) :905-913
[10]   IL-21 down-regulates NKG2D/DAP10 express on human NK and CD8+ T cells [J].
Burgess, SJ ;
Marusina, AI ;
Pathmanathan, I ;
Borrego, F ;
Coligan, JE .
JOURNAL OF IMMUNOLOGY, 2006, 176 (03) :1490-1497
123456789