3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration

被引：297

作者：

Zhang, Meng ^{[1
,2
]}

Lin, Rongcai ^{[1
]}

Wang, Xin ^{[1
,2
]}

Xue, Jianmin ^{[1
,2
]}

Deng, Cuijun ^{[1
,2
]}

Feng, Chun ^{[1
,2
]}

Zhuang, Hui ^{[1
,2
]}

Ma, Jingge ^{[1
,2
]}

Qin, Chen ^{[1
,2
]}

Wan, Li ^{[3
]}

Chang, Jiang ^{[1
,2
]}

Wu, Chengtie ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

[3] Beijing Ten Dimens Technol Co Ltd, Beijing 100084, Peoples R China

来源：

SCIENCE ADVANCES | 2020年 / 6卷 / 12期

基金：

中国国家自然科学基金;

关键词：

MESENCHYMAL STEM-CELLS; ENDOTHELIAL-CELLS; DIFFERENTIATION; HYDROGEL; GELATIN;

D O I：

10.1126/sciadv.aaz6725

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic bone tissue engineering scaffolds. Herein, a Haversian bone- mimicking scaffold with integrated hierarchical Haversian bone structure was successfully prepared via digital laser processing (DLP)-based 3D printing. The compressive strength and porosity of scaffolds could be well controlled by altering the parameters of the Haversian bone-mimicking structure. The Haversian bone-mimicking scaffolds showed great potential for multicellular delivery by inducing osteogenic, angiogenic, and neurogenic differentiation in vitro and accelerated the ingrowth of blood vessels and new bone formation in vivo. The work offers a new strategy for designing structured and functionalized biomaterials through mimicking native complex bone tissue for tissue regeneration.

引用

页数：12

共 40 条

[1] Common mechanisms of nerve and blood vessel wiring [J].