Modeling estrogen receptor-positive breast cancers in mice: is it the best we can do?

被引：6

作者：

Chatzistamou, Ioulia ^{[1
]}

Kiaris, Hippokratis ^{[2
,3
,4
]}

机构：

[1] Univ South Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC USA

[2] Univ South Carolina, Sch Med, Dept Drug Discovery & Biomed Sci, Columbia, SC 29208 USA

[3] Univ South Carolina, Res Off, Peromyscus Genet Stock Ctr, Columbia, SC 29208 USA

[4] Univ Athens, Sch Med, Dept Biochem, Athens, Greece

来源：

关键词：

estrogen receptor; cancer model; estrogen supplementation; breast cancer; CYCLOSPORINE-TREATED MICE; ESTRADIOL; PLASMA; RATS;

D O I：

10.1530/ERC-16-0397

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The continuous supplementation of mice with supraphysiological doses of estrogen for the growth of estrogen receptor-positive breast cancers has been linked to toxicity in the host and perturbation of cancer cells' function that can misguide preclinical studies. Thus, alternative experimental models with circulating levels of estrogens higher than those of mice may represent more suitable hosts to model estrogen receptor-positive breast cancers.

引用

页码：C9 / C12

页数：4

共 17 条

[1]

[Anonymous], AM SOC MAMMOLOGISTS

[2]

BATRA S, 1979, J REPROD FERTIL, V56, P1, DOI 10.1530/jrf.0.0560001

[3] EVALUATION OF CYCLOSPORINE-TREATED MICE AS HOSTS FOR GROWING AND TESTING THE CHEMOSENSITIVITY OF 1ST-TRANSPLANT-GENERATION HUMAN-TUMOR XENOGRAFTS IMPLANTED UNDER THE KIDNEY CAPSULE [J].