Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage

被引：94

作者：

Bhowmick, Debasish ^{[1
]}

Srivastava, Shubhi ^{[2
]}

D'Silva, Patrick ^{[2
]}

Mugesh, Govindasamy ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 29期

关键词：

antioxidants; DNA damage; glutathione peroxidase; reactive oxygen species; selenium; THIOREDOXIN; EBSELEN; INHIBITION; CHEMISTRY; MECHANISM; SUBSTRATE; REDUCTASE; STRESS; MODEL;

D O I：

10.1002/anie.201502430

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel isoselenazoles with high glutathione peroxidase (GPx) and peroxiredoxin (Prx) activities provide remarkable cytoprotection to human cells, mainly by exhibiting antioxidant activities in the presence of cellular thiols. The cytotoxicity of the isoselenazoles is found to be significantly lower than that of ebselen, which is being clinically evaluated by several groups for the treatment of reperfusion injuries and stroke, hearing loss, and bipolar disorder. The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species.

引用

页码：8449 / 8453

页数：5

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