Massive Gastrointestinal Bleeding as an Initial Presentation of Hodgkin Lymphoma

Hodgkin lymphoma is the most common malignant neoplasm affecting adolescents and young adults. Patients with Hodgkin lymphoma typically present with lymph node enlargement and systemic symptoms such as fever, weight loss, and night sweats. In addition, 40% of patients present with mediastinal mass-related symptoms such as cough and shortness of breath. Herein, we report a case of Hodgkin lymphoma with an unusual symptom, massive upper gastrointestinal bleeding. The bleeding persisted despite multiple endoscopic and hemostatic management. However, initiation of chemotherapeutic regimen stopped the bleeding. This posed the question of whether HL is a potential cause of massive upper GI bleeding.