Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones

被引：171

作者：

Chen, Qing-An ^{[1
]}

Chen, Mu-Wang ^{[1
]}

Yu, Chang-Bin ^{[1
]}

Shi, Lei ^{[1
]}

Wang, Duo-Sheng ^{[1
]}

Yang, Yan ^{[1
]}

Zhou, Yong-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 41期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE TRANSFER HYDROGENATION; ORGANOCATALYTIC TRANSFER HYDROGENATION; BRONSTED ACID CATALYSIS; ALPHA-IMINO ESTERS; CHIRAL PHOSPHORIC-ACIDS; TRANSITION-METAL; COOPERATIVE CATALYSIS; REDUCTIVE AMINATION; RELAY CATALYSIS; IRIDIUM;

D O I：

10.1021/ja208073w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic amount of Hantzsch ester that could be regenerated in situ by Ru complexes under hydrogen gas has been employed in the biomimetic asymmetric hydrogenation of benzoxazinones with up to 99% ee in the presence of chiral phosphoric acid. The use of hydrogen gas as a reductant for the regeneration of Hantzsch esters makes this hydrogenation an ideal atom economic process.

引用

页码：16432 / 16435

页数：4

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