Cytotoxic Activity of Crude Extracts as well as of Pure Components from Jatropha Species, Plants Used Extensively in African Traditional Medicine

被引:30
作者
Aiyelaagbe, Olapeju O. [1 ]
Hamid, Amao A. [2 ]
Fattorusso, Ernesto [3 ]
Taglialatela-Scafati, Orazio [3 ]
Schroeder, Heinz C. [4 ]
Mueller, Werner E. G. [4 ]
机构
[1] Univ Ibadan, Dept Chem, Ibadan 200284, Nigeria
[2] Univ Ilorin, Dept Chem, Ilorin 24003, Nigeria
[3] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy
[4] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, D-55128 Mainz, Germany
关键词
CURCAS; DITERPENES; AVAROL; VIRUS; ROOTS; AGENT; CELLS;
D O I
10.1155/2011/134954
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Extracts from Jatropha curcas, a plant used in African traditional medicine for various diseases, were tested for cytotoxic activity. The root extracts strongly reduced cell growth of tumor cells in vitro, a result consistent with the knowledge of the application of these plant extracts in traditional medicine, especially to cure/ameliorate cancer. A selection of pure diterpenoids existing in extracts from Jatropha species and isolated from J. curcas, for example, curcusone C, curcusone D, multidione, 15-epi-4Z-jatrogrossidentadion, 4Z-jatrogrossidentadion, 4E-jatrogrossidentadion, 2-hydroxyisojatrogrossidion, and 2-epi-hydroxyisojatrogrossidion, were likewise tested, and they also showed strong cytotoxic activity. It turned out that these extracts are highly active against L5178y mouse lymphoma cells and HeLa human cervix carcinoma cells, while they cause none or only very low activity against neuronal cell, for example, PC12. These data underscore that extracts from J. curcas or pure secondary metabolites from the plant are promising candidates to be anticancer drug, combined with low neuroactive effects.
引用
收藏
页数:7
相关论文
共 52 条
[31]   Antimicrobial, Antioxidant and Cytotoxic Activities and Phytochemical Screening of Some Yemeni Medicinal Plants [J].
Mothana, Ramzi A. A. ;
Abdo, Salah A. A. ;
Hasson, Sidgi ;
Althawab, Faisal M. N. ;
Alaghbari, Sama A. Z. ;
Lindequist, Ulrike .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2010, 7 (03) :323-330
[32]  
Muangman S, 2005, IN VIVO, V19, P265
[33]  
MUELLER W E G, 1977, Cancer Research, V37, P3824
[34]   Anti-inflammatory activity of Jatropha curcas roots in mice and rats [J].
Mujumdar, AM ;
Misar, A .
JOURNAL OF ETHNOPHARMACOLOGY, 2004, 90 (01) :11-15
[35]  
MULLER WEG, 1985, CANCER RES, V45, P4822
[36]   ISOLATION AND STRUCTURE DETERMINATION OF 4 NOVEL DITERPENES FROM JATROPHA-CURCUS [J].
NAENGCHOMNONG, W ;
THEBTARANONTH, Y ;
WIRIYACHITRA, P ;
OKAMOTO, KT ;
CLARDY, J .
TETRAHEDRON LETTERS, 1986, 27 (22) :2439-2442
[37]  
Oliver-Bever B., 1986, Medicinal plants in tropical West Africa
[38]   Coagulant and anticoagulant activities in Jatropha curcas latex [J].
Osoniyi, O ;
Onajobi, F .
JOURNAL OF ETHNOPHARMACOLOGY, 2003, 89 (01) :101-105
[39]   New lathyrane and podocarpane diterpenoids from Jatropha curcas [J].
Ravindranath, N ;
Reddy, MR ;
Ramesh, C ;
Ramu, R ;
Prabhakar, A ;
Jagadeesh, B ;
Das, B .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (05) :608-611
[40]   Toxic activities of the plant Jatropha curcas against intermediate snail hosts and larvae of schistosomes [J].
Rug, M ;
Ruppel, A .
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2000, 5 (06) :423-430