Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor

被引：25

作者：

Hou, Xue-Mei ^{[1
,2
,3
]}

Zhang, Ya-Hui ^{[1
,2
]}

Hai, Yang ^{[1
,2
]}

Zheng, Ji-Yong ^{[3
]}

Gu, Yu-Cheng ^{[4
]}

Wang, Chang-Yun ^{[1
,2
,5
]}

Shao, Chang-Lun ^{[1
,2
,3
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266200, Peoples R China

[3] Luoyang Ship Mat Res LSMRI, State Key Lab Marine Corros & Protect, Qingdao 266061, Peoples R China

[4] Jealotts Hill Int Res Ctr, Syngenta, Bracknell RG42 6EY, Berks, England

[5] Ocean Univ China, Inst Evolut & Marine Biodivers, Qingdao 266003, Peoples R China

来源：

MARINE DRUGS | 2017年 / 15卷 / 11期

基金：

中国国家自然科学基金;

关键词：

gorgonian-derived fungus; Carijoa sp; Aspergillus versicolor; centrosymmetric cyclohexapeptide; cytotoxicity; BIOLOGICAL-ACTIVITIES; FUSARIUM-OXYSPORUM; NATURAL-PRODUCTS; CELL; CYCLODEPSIPEPTIDE; BASSIANOLIDE; DERIVATIVES; ENNIATINS; POTENT; CONSTITUENTS;

D O I：

10.3390/md15110363

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new centrosymmetric cyclohexapeptide, aspersymmetide A (1), together with a known peptide, asperphenamate (2), was isolated from the fungus Aspergillus versicolor isolated from a gorgonian coral Carijoa sp., collected from the South China Sea. The chemical structure of 1 was elucidated by analyzing its NMR spectroscopy and MS spectrometry data, and the absolute configurations of the amino acids of 1 were determined by Marfey's method and UPLC-MS analysis of the hydrolysate. Aspersymmetide A (1) represents the first example of marine-derived centrosymmetric cyclohexapeptide. Moreover, 1 exhibited weak cytotoxicity against NCI-H292 and A431 cell lines at the concentration of 10 M.

引用

页数：8

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