Berberine inhibits glioma cell migration and invasion by suppressing TGF-β1/COL11A1 pathway

被引：17

作者：

Sun, Yuxue ^{[1
,2
,3
]}

Huang, Haiyan ^{[3
]}

Zhan, Zhixin ^{[3
]}

Gao, Haijun ^{[3
]}

Zhang, Chaochao ^{[3
]}

Lai, Jiacheng ^{[3
]}

Cao, Junguo ^{[3
,4
]}

Li, Chaoyue ^{[1
,2
]}

Chen, Yong ^{[3
]}

Liu, Ziqiang ^{[1
,2
,3
]}

机构：

[1] Zhengzhou Univ, Peoples Hosp, Cerebrovasc Dis Hosp, Henan Prov Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China

[2] Henan Univ, Peoples Hosp, Cerebrovasc Dis Hosp, Henan Prov Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China

[3] First Hosp Jilin Univ, Dept Neurosurg, Changchun 130021, Jilin, Peoples R China

[4] Heidelberg Univ, Dept Neurosurg, Div Expt Neurosurg, D-69120 Heidelberg, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2022年 / 625卷

关键词：

Berberine; COL11A1; Invasion; Migration; Glioma; OVARIAN-CANCER CELLS; COL11A1; CHEMORESISTANCE; PROLIFERATION; TEMOZOLOMIDE; METASTASIS; ACTIVATION; BIOMARKER; RECURRENT;

D O I：

10.1016/j.bbrc.2022.07.101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glioma is a clinically heterogeneous disease with a poor prognosis. Berberine (BBR), as a multi-target anti-tumor alkaloid, has the ability to penetrate the blood-brain barrier and shows cytotoxicity to glioma cells. In previous studies, we demonstrated that berberine inhibits glioma cell proliferation by inhibiting mutant p53 protein and promoting mitochondrial damage. In addition, berberine has been shown to reduce collagen accumulation in pulmonary fibrosis, diabetic nephropathy and arthritis. However, its effect on collagen in cancer needs to be further elucidated. In this study, we proved that the collagen XI alpha 1 chain (COL11A1) is highly expressed in glioma cell lines and associated with migration and invasion of glioma cells. Knocking down COL11A1 caused decreased expression of MMPs. Berberine could inhibit the migration and invasion of glioma cells by suppressing the TGF-beta 1/COL11A1 pathway and changes actin cytoskeleton arrangement. Nude mouse subcutaneous xenografts model also showed that berberine inhibited the expression of COL11A1 in vivo. Collectively, berberine that targets COL11A1 to inhibit glioma migration and invasion, may serve as a promising candidate for the development of anti-glioma drugs in the future. (C) 2022 Elsevier Inc. All rights reserved.

引用

页码：38 / 45

页数：8

共 32 条

[1] TGF-β1 targets a microRNA network that regulates cellular adhesion and migration in renal cancer [J].

Boguslawska, Joanna ;

Rodzik, Katarzyna ;

Poplawski, Piotr ;

Kedzierska, Hanna ;

Rybicka, Beata ;

Sokol, Elzbieta ;

Tanski, Zbigniew ;

Piekielko-Witkowska, Agnieszka .

CANCER LETTERS, 2018, 412 :155-169

[2] Glioma Subclassifications and Their Clinical Significance [J].

Chen, Ricky ;

Smith-Cohn, Matthew ;

Cohen, Adam L. ;

Colman, Howard .

NEUROTHERAPEUTICS, 2017, 14 (02) :284-297

[3] A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer [J].

Cheon, Dong-Joo ;

Tong, Yunguang ;

Sim, Myung-Shin ;

Dering, Judy ;

Berel, Dror ;

Cui, Xiaojiang ;

Lester, Jenny ;

Beach, Jessica A. ;

Tighiouart, Mourad ;

Walts, Ann E. ;

Karlan, Beth Y. ;

Orsulic, Sandra .

CLINICAL CANCER RESEARCH, 2014, 20 (03) :711-723

[4] Berberine inhibits Smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis [J].

Chitra, Palanivel ;

Saiprasad, Gowrikumar ;

Manikandan, Ramar ;

Sudhandiran, Ganapasam .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2015, 93 (09) :1015-1031

[5] Berberine and Its Role in Chronic Disease [J].

Cicero, Arrigo F. G. ;

Baggioni, Alessandra .

ANTI-INFLAMMATORY NUTRACEUTICALS AND CHRONIC DISEASES, 2016, 928 :27-45

[6] Validation of COL11A1/procollagen 11A1 expression in TGF-β1-activated immortalised human mesenchymal cells and in stromal cells of human colon adenocarcinoma [J].

Galvan, Jose A. ;

Garcia-Martinez, Jorge ;

Vazquez-Villa, Fernando ;

Garcia-Ocana, Marcos ;

Garcia-Pravia, Carmen ;

Menendez-Rodriguez, Primitiva ;

Gonzalez-del Rey, Carmen ;

Barneo-Serra, Luis ;

de los Toyos, Juan R. .

BMC CANCER, 2014, 14

[7] Current knowledge and pharmacological profile of berberine: An update [J].

Kumar, Anil ;

Ekavali ;

Chopra, Kanwaljit ;

Mukherjee, Madhurima ;

Pottabathini, Raghavender ;

Dhull, Dinesh K. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2015, 761 :288-297

[8] Collagen XI alpha 1 chain, a potential therapeutic target for cancer [J].

Liu, Ziqiang ;

Lai, Jiacheng ;

Jiang, Heng ;

Ma, Chengyuan ;

Huang, Haiyan .

FASEB JOURNAL, 2021, 35 (06)

[9] Berberine Inhibits Cell Proliferation by Interfering with Wild-Type and Mutant P53 in Human Glioma Cells [J].

Liu, Ziqiang ;

Chen, Yong ;

Gao, Haijun ;

Xu, Weidong ;

Zhang, Chaochao ;

Lai, Jiacheng ;

Liu, Xingxing ;

Sun, Yuxue ;

Huang, Haiyan .

ONCOTARGETS AND THERAPY, 2020, 13 :12151-12162

[10] Lamellipodia and filopodia in metastasis and invasion [J].

Machesky, Laura M. .

FEBS LETTERS, 2008, 582 (14) :2102-2111

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