Renal hemodynamic dysfunction and neuropathy in longstanding type 1 diabetes: Results from the Canadian study of longevity in type 1 diabetes

被引：1

作者：

Lytvyn, Yuliya ^{[1
]}

Albakr, Rehab ^{[1
,9
]}

Bjornstad, Petter ^{[2
,5
]}

Lovblom, Leif Erik ^{[3
]}

Liu, Hongyan ^{[1
]}

Lovshin, Julie A. ^{[4
]}

Boulet, Genevieve ^{[4
]}

Farooqi, Mohammed A. ^{[4
]}

Weisman, Alanna ^{[4
]}

Brent, Michael H. ^{[6
]}

Paul, Narinder ^{[7
]}

Bril, Vera ^{[8
]}

Perkins, Bruce A. ^{[4
]}

Cherney, David Z. I. ^{[1
,10
]}

机构：

[1] Univ Toronto, Toronto Gen Hosp, Dept Med, Div Nephrol, Toronto, ON, Canada

[2] Univ Colorado, Dept Pediat, Div Endocrinol, Sch Med, Aurora, CO USA

[3] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[4] Univ Toronto, Mt Sinai Hosp, Dept Med, Div Endocrinol & Metab, Toronto, ON, Canada

[5] Joslin Diabet Ctr, Res Div, Boston, MA USA

[6] Univ Toronto, Dept Ophthalmol & Vis Sci, Dept Med, Toronto, ON, Canada

[7] Univ Hlth Network, Joint Dept Med Imaging, Div Cardiothorac Radiol, Toronto, ON, Canada

[8] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[9] King Saud Univ, Coll Med, Div Nephrol, Riyadh, Saudi Arabia

[10] Toronto Gen Hosp, 585 Univ Ave, 8N-845, Toronto, ON M5G 2N2, Canada

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2022年 / 36卷 / 11期

关键词：

Type; 1; diabetes; Renal hemodynamic function; Neuropathy; Retinopathy; Heart rate variability; CORNEAL CONFOCAL MICROSCOPY; FOOT ULCERATION; RISK-FACTORS; INHIBITION; SEVERITY; POLYNEUROPATHY; COMPLICATIONS; RELIABILITY; HUMANS;

D O I：

10.1016/j.jdiacomp.2022.108320

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: To determine the relationship between renal hemodynamic function and neuropathy in adults with >= 50years of type 1 diabetes (T1D) compared to nondiabetic controls. Methods: Glomerular filtration rate (GFR, inulin), effective renal plasma flow (ERPF, p-aminohippurate), modified Toronto Clinical Neuropathy Score (mTCNS), corneal confocal microscopy, nerve conduction, and heart rate variability (autonomic function) were measured; afferent (RA) and efferent (RE) arteriolar resistances were estimated using the Gomez equations in 74 participants with T1D and in 75 controls. Diabetic kidney disease (DKD) non-resistors were defined by eGFRMDRD < 60 ml/min/1.73 m2 or 24-h urine albumin excretion >30 mg/ day. Linear regression was applied to examine the relationships between renal function (dependent variable) and neuropathy measures (independent variable), adjusted for age, sex, HbA1c, systolic blood pressure, low density lipoprotein cholesterol, and 24-h urine albumin to creatinine ratio. Results: Higher mTCNS associated with lower renal blood flow (beta +/- SE:-9.29 +/- 4.20, p = 0.03) and greater RE (beta +/- SE:32.97 +/- 15.43, p = 0.04) in participants with T1D, but not in controls. DKD non-resistors had a higher mTCNS and worse measures of corneal nerve morphology compared to those without DKD. Renal hemodynamic parameters did not associate with autonomic nerve function. Conclusions: Although neurological dysfunction in the presence of diabetes may contribute to impaired renal blood flow resulting in ischemic injury in patients with T1D, early autonomic dysfunction does not appear to be associated with kidney function changes.

引用

页数：10

共 43 条

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