Behavioral epigenetics

被引:88
作者
Lester, Barry M. [1 ,2 ]
Tronick, Edward [3 ,4 ]
Nestler, Eric [5 ]
Abel, Ted [6 ]
Kosofsky, Barry [7 ]
Kuzawa, Christopher W. [8 ]
Marsit, Carmen J. [9 ]
Maze, Ian [10 ]
Meaney, Michael J. [11 ,12 ,13 ]
Monteggia, Lisa M. [14 ]
Reul, Johannes M. H. M. [15 ]
Skuse, David H. [16 ]
Sweatt, J. David [17 ]
Wood, Marcelo A. [18 ]
机构
[1] Brown Univ, Brown Ctr Study Children Risk, Women & Infants Hosp, Warren Alpert Med Sch,Dept Psychiat, Providence, RI 02908 USA
[2] Brown Univ, Dept Human Behav & Pediat, Women & Infants Hosp, Warren Alpert Med Sch, Providence, RI 02908 USA
[3] Univ Massachusetts, Dept Psychol, Boston, MA 02125 USA
[4] Harvard Univ, Sch Med, Childrens Hosp Boston, Child Dev Unit, Boston, MA USA
[5] Mt Sinai Sch Med, Mt Sinai Brain Inst, Dept Neurosci, Fishberg Dept Neurosci, New York, NY USA
[6] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
[7] New York Presbyterian Hosp, Weill Cornell Med Ctr, Div Pediat Neurol, New York, NY USA
[8] Northwestern Univ, Inst Policy Res, Evanston, IL USA
[9] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA
[10] Rockefeller Univ, Lab Chromatin Biol & Epigenet, New York, NY 10021 USA
[11] McGill Univ, Dept Psychiat, Montreal, PQ, Canada
[12] McGill Univ, Dept Neurol, Montreal, PQ H3A 2T5, Canada
[13] McGill Univ, Dept Neurosurg, Montreal, PQ H3A 2T5, Canada
[14] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA
[15] Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol, Avon, England
[16] UCL, Inst Child Hlth, Behav & Brain Sci Unit, London, England
[17] Univ Alabama Birmingham, Dept Neurobiol, Birmingham, AL USA
[18] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA
来源
ANNALS MEETING REPORTS | 2011年 / 1226卷
基金
美国国家卫生研究院;
关键词
behavior; epigenetics; chromosome; gene regulation; transcription; methylation; MESSENGER-RNA EXPRESSION; PARENT-OF-ORIGIN; HISTONE ACETYLTRANSFERASE ACTIVITY; GENOMIC DNA HYPERMETHYLATION; ATRIAL-NATRIURETIC-PEPTIDE; CULTURED CORTICAL-NEURONS; RUBINSTEIN-TAYBI-SYNDROME; GYRUS GRANULE NEURONS; RECEPTOR NR2B GENE; BDNF GENE;
D O I
10.1111/j.1749-6632.2011.06037.x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Sponsored by the New York Academy of Sciences, the Warren Alpert Medical School of Brown University and the University of Massachusetts Boston, "Behavioral Epigenetics" was held on October 29-30, 2010 at the University of Massachusetts Boston Campus Center, Boston, Massachusetts. This meeting featured speakers and panel discussions exploring the emerging field of behavioral epigenetics, from basic biochemical and cellular mechanisms to the epigenetic modulation of normative development, developmental disorders, and psychopathology. This report provides an overview of the research presented by leading scientists and lively discussion about the future of investigation at the behavioral epigenetic level.
引用
收藏
页码:14 / 33
页数:20
相关论文
共 118 条
[1]   Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice:: A model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration [J].
Alarcón, JM ;
Malleret, G ;
Touzani, K ;
Vronskaya, S ;
Ishii, S ;
Kandel, ER ;
Barco, A .
NEURON, 2004, 42 (06) :947-959
[2]   Variation in the Large-Scale Organization of Gene Expression Levels in the Hippocampus Relates to Stable Epigenetic Variability in Behavior [J].
Alter, Mark D. ;
Rubin, Daniel B. ;
Ramsey, Keri ;
Halpern, Rebecca ;
Stephan, Dietrich A. ;
Abbott, L. F. ;
Hen, Rene .
PLOS ONE, 2008, 3 (10)
[3]   Altered gene activity correlated with long-term memory formation of conditioned taste aversion in Lymnaea [J].
Azami, Sachiyo ;
Wagatsuma, Akiko ;
Sadamoto, Hisayo ;
Hatakeyama, Dai ;
Usami, Takeshi ;
Fujie, Manabu ;
Koyanagi, Ryo ;
Azumi, Kaoru ;
Fujito, Yutaka ;
Lukowiak, Ken ;
Ito, Etsuro .
JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 84 (07) :1610-1620
[4]   Artificial microRNA-based neurokinin-1 receptor gene silencing reduces alcohol consumption in mice [J].
Baek, Mi Na ;
Jung, Kyoung Hwa ;
Halder, Debasish ;
Choi, Mi Ran ;
Lee, Byung-Hwa ;
Lee, Boung-Chul ;
Jung, Myung Hun ;
Choi, Ihn-Geun ;
Chung, Mi-Kyung ;
Oh, Dong-Yul ;
Chai, Young Gyu .
NEUROSCIENCE LETTERS, 2010, 475 (03) :124-128
[5]  
BARRETT RM, 2011, NEUROPSYCHOPHAR 0420
[6]   Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor-dependent behavioural response [J].
Bilang-Bleuel, A ;
Ulbricht, S ;
Chandramohan, Y ;
De Carli, S ;
Droste, SK ;
Reul, JMHM .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 22 (07) :1691-1700
[7]   Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence [J].
Bleich, S ;
Lenz, B ;
Ziegenbein, M ;
Beutler, S ;
Frieling, H ;
Kornhuber, J ;
Bönsch, D .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2006, 30 (04) :587-591
[8]   Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism [J].
Boensch, D. ;
Lenz, B. ;
Fiszer, R. ;
Frieling, H. ;
Kornhuber, J. ;
Bleich, S. .
JOURNAL OF NEURAL TRANSMISSION, 2006, 113 (09) :1299-1304
[9]  
Bönsch D, 2005, NEUROREPORT, V16, P167
[10]   Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism [J].
Bönsch, D ;
Lenz, B ;
Reulbach, U ;
Kornhuber, J ;
Bleich, S .
JOURNAL OF NEURAL TRANSMISSION, 2004, 111 (12) :1611-1616