Mitochondrial DNA metabolism targeting drugs

被引：41
作者：
Rowe, TC [1 ]
Weissig, V
Lawrence, JW
机构：
[1] Univ Florida, Coll Med, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA
[2] Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA
[3] Merck & Co Inc, W Point, PA 19486 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2001年 / 49卷 / 1-2期
关键词：
intercalator; dideoxynucleoside; mitochondria; topoisomerase; polyamine; replication; inhibitor; polymerase; viral; lipophilic;
D O I：
10.1016/S0169-409X(01)00133-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Numerous drugs are known to deplete mitochondrial DNA (mtDNA) from mammalian cells. These include DNA polymerase gamma and type II topoisomerase inhibitors, lipophilic cationic compounds, and DNA intercalating and non intercalating agents. The effects of these drugs on mtDNA metabolism will be discussed and potential mechanisms underlying their depletion of mtDNA presented. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：175 / 187
页数：13
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