Bruton's Tyrosine Kinase: An Emerging Key Player in Innate Immunity

被引:211
作者
Weber, Alexander N. R. [1 ]
Bittner, Zsofia [1 ]
Liu, Xiao [1 ]
Truong-Minh Dang [1 ]
Radsak, Markus Philipp [2 ]
Brunner, Cornelia [3 ]
机构
[1] Univ Tubingen, Interfac Inst Cell Biol, Dept Immunol, Tubingen, Germany
[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Internal Med 3, Mainz, Germany
[3] Ulm Univ, Dept Otorhinolaryngol, Med Ctr, Ulm, Germany
关键词
Bruton's tyrosine kinase; macrophage; dendritic cell; Toll-like receptor; NLRP3; inflammasome; ibrutinib; X-linked agammaglobulinemia; X-LINKED AGAMMAGLOBULINEMIA; T-CELL IG; NLRP3; INFLAMMASOME; B-CELL; THERAPEUTIC TARGET; MUCIN PROTEIN-3; DENDRITIC CELLS; MYELOID CELLS; BTK; RECEPTOR;
D O I
10.3389/fimmu.2017.01454
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Bruton's tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell receptor signaling in the development and functioning of adaptive immunity. Growing evidence also suggests multiple roles for BTK in mononuclear cells of the innate immune system, especially in dendritic cells and macrophages. For example, BTK has been shown to function in Toll-like receptor-mediated recognition of infectious agents, cellular maturation and recruitment processes, and Fc receptor signaling. Most recently, BTK was additionally identified as a direct regulator of a key innate inflammatory machinery, the NLRP3 inflammasome. BTK has thus attracted interest not only for gaining a more thorough basic understanding of the human innate immune system but also as a target to therapeutically modulate innate immunity. We here review the latest developments on the role of BTK in mononuclear innate immune cells in mouse versus man, with specific emphasis on the sensing of infectious agents and the induction of inflammation. Therapeutic implications for modulating innate immunity and critical open questions are also discussed.
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页数:6
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