Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids

被引：29

作者：

Deasy, Rebecca E. ^{[1
]}

Brossat, Maude ^{[2
]}

Moody, Thomas S. ^{[2
]}

Maguire, Anita R. ^{[1
,3
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Dept Chem, Analyt & Biol Chem Res Facil, Cork, Ireland

[2] Almac Sci, Biocatalysis Grp, Belfast BT9 5AG, Antrim, North Ireland

[3] Natl Univ Ireland Univ Coll Cork, Sch Pharm, Analyt & Biol Chem Res Facil, Cork, Ireland

来源：

TETRAHEDRON-ASYMMETRY | 2011年 / 22卷 / 01期

关键词：

CANDIDA-RUGOSA LIPASE; OPTICALLY PURE ISOMERS; UNUSUAL AMINO-ACIDS; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; IMMOBILIZED LIPASE; ENZYMES; ESTERIFICATION; ESTERS; ISOMERIZATION;

D O I：

10.1016/j.tetasy.2010.12.019

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (>= 94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：47 / 61

页数：15

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