Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations

被引:68
作者
Finegersh, Andrey [1 ]
Rompala, Gregory R. [2 ]
Martin, David I. K. [3 ]
Homanics, Gregg E. [1 ,4 ]
机构
[1] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA
[2] Univ Pittsburgh, Sch Med, Ctr Neurosci, Pittsburgh, PA USA
[3] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA
[4] Univ Pittsburgh, Sch Med, Dept Anesthesiol, Pittsburgh, PA 15261 USA
关键词
Alcoholism; Transgenerational inheritance; Epigenetics; DNA methylation; Histones; ncRNAs; GENOME-WIDE ASSOCIATION; HIGH-FAT DIET; DNA METHYLATION; EPIGENETIC INHERITANCE; SMALL RNAS; TRANSGENERATIONAL INHERITANCE; BIRTH-WEIGHT; BODY SWAY; IN-VIVO; CONSUMPTION;
D O I
10.1016/j.alcohol.2015.02.008
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Alcohol-use disorder (AUD) is prevalent and associated with substantial socioeconomic costs. While heritability estimates of AUD are similar to 50%, identifying specific gene variants associated with risk for AUD has proven challenging despite considerable investment. Emerging research into heritability of complex diseases has implicated transmission of epigenetic variants in the development of behavioral phenotypes, including drug preference and drug-induced behavior. Several recent rodent studies have specifically focused on paternal transmission of epigenetic variants, which is especially relevant because sires are not present for offspring rearing and changes to offspring phenotype are assumed to result from modifications to the sperm epigenome. While considerable interest in paternal transmission of epigenetic variants has emerged recently, paternal alcohol exposures have been studied for 30+ years with interesting behavioral and physiologic effects noted on offspring. However, only recently, with improvements in technology to identify epigenetic modifications in germ cells, has it been possible to identify mechanisms by which paternal ethanol exposure alters offspring behavior. This review presents an overview of epigenetic inheritance in the context of paternal ethanol exposure and suggests future studies to identify specific effects of paternal ethanol exposure on offspring behavior and response to ethanol. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:461 / 470
页数:10
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