Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation

被引:15
|
作者
Joshi, Sunil K. [1 ]
Lang, Gillian A. [1 ]
Devera, T. Scott [1 ]
Johnson, Amy M. [1 ]
Kovats, Susan [2 ]
Lang, Mark L. [1 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA
[2] Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA
关键词
antibody; alpha-galactosylceramide; antigen presentation; adaptive immunity; ALPHA-GALACTOSYLCERAMIDE LEADS; IN-VIVO; LIPID ANTIGEN; B-CELLS; RESPONSES; INNATE; HELP; STIMULATION; LYMPHOCYTES; MATURATION;
D O I
10.1189/jlb.1111559
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
CD1d-restricted type I NKT cells provide help for specific antibody production. B cells, which have captured and presented a T-dependent, antigen-derived peptide on MHC class II and CD1d-binding glycolipid alpha-GC on CD1d, respectively, activate Th and NKT cells to elicit B cell help. However, the role of the DC CD1d in humoral immunity remains unknown. We therefore constructed mixed bone marrow chimeras containing CD1d-expressing, DTR-transgenic DCs and CD1d(+) or CD1d(-) nontransgenic DCs. Following DT-mediated DC ablation and immunization, we observed that the primary and secondary antibody responses were equivalent in the presence of CD1d(+) and CD1d(-) DCs. In contrast, a total ablation of DCs delayed the primary antibody response. Further experiments revealed that depletion of CD1d(+) DCs blocked in vivo expansion of antigen-specific cytotoxic (CD8(+)) T lymphocytes. These results provide a clear demonstration that although CD1d expression on DCs is essential for NKT-enhanced CD8(+) T cell expansion, it is dispensable for specific antibody production. J. Leukoc. Biol. 91: 783-790; 2012.
引用
收藏
页码:783 / 790
页数:8
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