Increased expression of aquaporin-4 in brain tissue of amygdala-kindled rats

被引：1

作者：

Chen, Yinghui ^{[2
]}

Zhao, Yongbo ^{[1
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai E Hosp, Dept Neurol, Shanghai 200120, Peoples R China

[2] Fudan Univ, Jinshan Hosp, Dept Neurol, Shanghai 200540, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 32期

基金：

上海市自然科学基金;

关键词：

epilepsy; aquaporin-4; brain edema; amygdala; neural regeneration; CENTRAL-NERVOUS-SYSTEM; EDEMA; INJURY; MICE;

D O I：

10.3969/j.issn.1673-5374.2011.32.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recurrent epileptic seizures can lead to brain edema, indicating that water regulation may be perturbed by seizures. We hypothesized that the expression of the brain water channel aquaporin-4 (AQP-4) may be upregulated in the epileptic brain. In the present study, we established the amygdala kindling model of epilepsy, and quantified AQP-4 protein and mRNA levels, using reverse transcription-PCR, immunohistochemistry and western blotting, in epileptic and control rats. We found that AQP-4 was overexpressed in the cerebral cortex of rats with epilepsy compared with controls. These findings show that AQP-4 is highly expressed in the brain of amygdala-kindled rats, suggesting that repeated seizures affect water homeostasis in the brain.

引用

页码：2495 / 2499

页数：5

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