The Role of the Gut Microbiome in Colorectal Cancer: Where Are We? Where Are We Going?

被引：44

作者：

Wieczorska, Karina ^{[1
]}

Stolarek, Malgorzata ^{[1
]}

Stec, Rafal ^{[2
]}

机构：

[1] Masovian Specialist Hosp, Oncol Dept, Radom, Poland

[2] Med Univ Warsaw, Dept Oncol, Zwirki & Wigury 61, PL-02091 Warsaw, Poland

来源：

CLINICAL COLORECTAL CANCER | 2020年 / 19卷 / 01期

关键词：

Cancerogenesis; Colon microorganisms; Dysfunction of the immune system; Microbiome dysbiosis; INTESTINAL EPITHELIAL-CELLS; COLON-CANCER; INFLAMMATION; CARCINOGENESIS; COMMENSAL; PROMOTES; TUMORIGENESIS; COLONIZATION; MAINTENANCE; BACTERIA;

D O I：

10.1016/j.clcc.2019.07.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Microbiome (microbiota) is a community of all microorganisms inhabiting a specific site of the body, including pathogens, which distinguishes it from the physiological microflora. Intestinal dysbiosis plays a key role in the development of colorectal cancer. In the process of carcinogenesis, inflammation, immune response, and toxic metabolites play a significant role. Specific species of bacteria might affect the risk of colorectal cancer and growth of tumor already present. Assessment of changes in the intestinal microbiome during the development and progression of colorectal cancer might create a simple diagnostic tool, a useful biomarker, or might influence treatment strategies in colorectal cancer patients. Analysis of the gut microbiome provides the potential to develop noninvasive diagnostic tests that would be useful as new protective markers of colorectal cancer, prognostic markers in already present colorectal cancer, and predictive markers of response to treatment, especially immunotherapy. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：5 / 12

页数：8

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