A New Phosphine-Amine-Oxazoline Ligand for Ru-Catalyzed Asymmetric Hydrogenation of N-Phosphinylimines

被引：10

作者：

Ma, Xiaochen ^{[1
]}

Qiao, Lin ^{[1
]}

Liu, Guixia ^{[1
]}

Huang, Zheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Univ Chinese Acad Sci, State Key Lab Organometall Chem, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2018年 / 36卷 / 12期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

amines; chiral ligand; hydrogenation; imines; ruthenium; ENANTIOSELECTIVE HYDROGENATION; IRIDIUM CATALYSTS; PINCER LIGANDS; KETONES; IMINES; HYDROSILYLATION; COMPLEXES; ALCOHOLS;

D O I：

10.1002/cjoc.201800343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of chiral phosphine-amine-oxazoline (PAO) ligands with an NH moiety were synthesized and applied to the ruthenium-catalyzed asymmetric hydrogenation of N-phosphinylimines. The ligand bearing phenyl groups at the phosphorus moiety and isopropyl at the oxazoline moiety exhibits good activity and excellent enantioselectivity (up to 99% ee). This catalytic system provides an efficient and mild approach to access enantioriched amines.

引用

页码：1151 / 1155

页数：5

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