Unexpectedly High Prevalence of Coronary Spastic Angina in Patients With Anderson-Fabry Disease

被引：11

作者：

Kitani, Yuya ^{[1
]}

Nakagawa, Naoki ^{[1
]}

Sakamoto, Naka ^{[1
]}

Takeuchi, Toshiharu ^{[1
]}

Takahashi, Fumihiko ^{[2
]}

Momosaki, Ken ^{[3
]}

Nakamura, Kimitoshi ^{[3
]}

Endo, Fumio ^{[3
]}

Maruyama, Hiroki ^{[4
]}

Hasebe, Naoyuki ^{[1
]}

机构：

[1] Asahikawa Med Univ, Dept Internal Med, Div Cardiol Nephrol Pulmonol & Neurol, Asahikawa, Hokkaido, Japan

[2] Rumoi City Hosp, Dept Cardiol, Rumoi, Japan

[3] Kumamoto Univ, Grad Sch Med Sci, Dept Pediat, Kumamoto, Japan

[4] Niigata Univ, Grad Sch Med & Dent Sci, Dept Clin Nephrosci, Niigata, Japan

来源：

CIRCULATION JOURNAL | 2019年 / 83卷 / 02期

基金：

日本学术振兴会;

关键词：

Acetylcholine-induced provocation test; Anderson-Fabry disease; Coronary spastic angina; VASOSPASTIC ANGINA;

D O I：

10.1253/circj.CJ-18-0734

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Although we and others have reported cases of patients with Anderson-Fabry disease (AFD) complicated by coronary spastic angina (CSA), the prevalence of CSA in these patients remains unknown. Methods and Results: We performed the acetylcholine-induced provocation test, according to the Japanese guidelines for the diagnosis and treatment of patients with CSA, in 9 consecutive patients having 5 independent AFD pedigrees. Coronary spasms were provoked in conjunction with symptoms and ECG ischemic changes in 8 of 9 (89%) patients with AFD. Conclusions: We found an unexpectedly high prevalence of CSA in patients with AFD.

引用

页码：481 / +

页数：7

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