Immunotherapy of lymphomas

被引：34

作者：

Ansell, Stephen M. ^{[1
]}

Lin, Yi ^{[1
]}

机构：

[1] Mayo Clin, Dept Hematol, 200 First St, Rochester, MN 55905 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2020年 / 130卷 / 04期

关键词：

CHIMERIC ANTIGEN RECEPTOR; B-CELL LYMPHOMA; ANTI-CD20; MONOCLONAL-ANTIBODY; LENALIDOMIDE PLUS RITUXIMAB; IMMUNOCONJUGATE INOTUZUMAB OZOGAMICIN; COLTUXIMAB RAVTANSINE SAR3419; CLASSICAL HODGKIN LYMPHOMA; BRENTUXIMAB VEDOTIN SGN-35; IN-SITU VACCINATION; CYTOTOXIC T-CELLS;

D O I：

10.1172/JCI129206

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lymphoid malignancies typically promote an infiltrate of immune cells at sites involved by the disease. While some of the immune cells present in lymphoma have effector function, the immune system is unable to eradicate the malignant clone. Therapies that optimize immune function therefore have the potential to improve the outcome of lymphoma patients. In this Review, we discuss immunologic approaches that directly target the malignant cell as well as approaches to optimize both the innate and adaptive immune response to the tumor. While many of these therapies have shown single-agent activity, the future will clearly require thoughtful combinations of these approaches.

引用

页码：1576 / 1585

页数：10

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