Analysis of a stochastic HIV-1 infection model with degenerate diffusion

This paper studies a stochastic HIV-1 infection model with degenerate diffusion. The asymptotic dynamics of the stochastic model are shown to be governed by a threshold parameter. When the parameter is negative, the infection is predicted to go extinct exponentially while the level of healthy cells converges weakly to a unique invariant measure. When the threshold parameter is positive, the solution of the stochastic model converges polynomially to a unique invariant probability measure, indicating that the system admits a unique ergodic stationary distribution. Numerical simulations are conducted to show the analytical results. These results highlight the role of environmental noise in the spread of HIV-1. The method can also be applied to the non-degenerate systems. (C) 2018 Elsevier Inc. All rights reserved.