Overexpression of COX7A2 is associated with a good prognosis in patients with glioma

被引：14
作者：
Deng, Shengze [1 ,2 ]
Li, Yaomin [1 ,2 ]
Yi, Guozhong [1 ,2 ]
Lei, Bingxi [1 ,2 ]
Guo, Manlan [2 ]
Xiang, Wei [1 ,2 ]
Chen, Ziyang [1 ,2 ]
Liu, Yawei [2 ]
Qi, Songtao [1 ,2 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Neurosurg, Guangzhou Dadao Bei St 1838, Guangzhou 510515, Guangdong, Peoples R China
[2] Southern Med Univ, Nanfang Hosp, Lab Precis Neurosurg, Guangzhou 510515, Guangdong, Peoples R China
来源：
JOURNAL OF NEURO-ONCOLOGY | 2018年 / 136卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cytochrome c oxidase subunit 7A2; Glioma; Prognosis; MITOCHONDRIAL DYSFUNCTION; MOLECULAR CLASSIFICATION; ADENOCARCINOMA; GLIOBLASTOMA; BIOMARKERS; IDENTIFY; CANCER; ADULTS;
D O I：
10.1007/s11060-017-2637-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytochrome c oxidase subunit 7A2 (COX7A2) is a nuclear-encoded polypeptide involved in assembly and regulation of cytochrome c oxidase (COX). Changes in the respiratory chain as big complex are known to be associated with cancer, but little research has been performed to discover COX7A2 as a prognostic marker in glioma. In the present study, we investigated COX7A2 expression and its prognostic significance in glioma. Glioma surgical tissue samples were taken from 126 patients who had been followed up from 4 to 51 months. Immunohistochemistry were used to test COX7A2 expression in the 126 tumor samples. Eighty-six of 126 (68.3%) paraffin-embedded glioma biopsies showed high expression of COX7A2. Statistical analysis displayed that there was significant difference of COX7A2 expression level in patients categorized according to WHO classification. Kaplan-Meier survival analysis revealed that patients with higher COX7A2 expression had longer overall survival time and better prognosis. R2: microarray analysis based on Tumor Glioma French 284 database, Tumor Glioblastoma TCGA 540 database, and Tumor Glioma Kawaguchi 50 database testified that high expression of COX7A2 is associated with a good prognosis in patients with glioma. Multivariate analysis showed that COX7A2 high expression was an independent prognostic indicator for survival. Our results suggest that COX7A2 could be served as a valuable prognostic marker of glioma.
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收藏
页码：41 / 50
页数：10
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