Tailoring x-ray beam energy spectrum to enhance image quality of new radiography contrast agents based on Gd or other lanthanides

被引:2
作者
Dilmanian, FA [1 ]
Weinmann, HJ [1 ]
Zhong, Z [1 ]
Bacarian, T [1 ]
Rigon, L [1 ]
Button, TM [1 ]
Ren, B [1 ]
Wu, YY [1 ]
Zhong, N [1 ]
Atkins, HL [1 ]
机构
[1] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA
来源
MEDICAL IMAGING 2001: PHYSICS OF MEDICAL IMAGING | 2001年 / 4320卷
关键词
radiography with contrast agent; CT with contrast agent; iodine contrast agent; gadolinium contrast agent; monochromatic x ray; x-ray monochromator; x-ray beam filtration; x-ray K-edge beam filtration; image contrast-to-noise ratio;
D O I
10.1117/12.430904
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Gadovist, a 1.0-molar Gd contrast agent from Schering AG, Berlin, Germany, in use in clinical MRI in Europe, was evaluated as a radiography contrast agent. In a collaboration,xith Brookhaven National Laboratory (BNL), Schering AG is developing several such lanthanide-based contrast agents, while BNL evaluates them using different x-ray beam energy spectra. These energy spectra include a "truly" monochromatic beam (0.2 keV energy bandwidth) from the National Synchrotron Light Source (NSLS), BNL, tuned above the Gd K-edge, and x-ray-tube beams from different kVp settings and beam filtrations. Radiographs of rabbits' kidneys were obtained with Gadovist at the NSLS. Furthermore, a clinical radiography system was used for imaging rabbits' kidneys comparing Gadovist and Conray, an iodinated contrast agent. The study, using 74 kVp and standard Al beam filter for Conray and 66 kVp and an additional 1.5 nim Cu beam filter for Gadovist, produced comparable images for Gadovist and Conray; the injection volumes were the same, while the radiation absorbed dose for Gadovist was slightly smaller. A bent-crystal silicon monochromator operating in the Laue diffraction mode was developed and tested with a conventional x-ray tube beam; it narrows the energy spectrum to about 4 keV around the anode tungsten's K alpha fine. Preliminary beam-flux results indicate that the method could be implemented in clinical CT if x-ray tubes with similar to twice higher output become available.
引用
收藏
页码:417 / 426
页数:10
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