ZHD-0501, a novel naturally occurring staurosporine analog from Actinomadura sp. 007

被引：48
作者：
Han, XX
Cui, CB [1 ]
Gu, QQ
Zhu, WM
Liu, HB
Gu, JY
Osada, H
机构：
[1] Ocean Univ China, Marine Drug & Food Inst, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China
[2] Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 36期
基金：
中国国家自然科学基金;
关键词：
indolocarbazole alkaloid; staurosporines; ZHD-0501; marine-derived actinomyces; Actinomadura; anticancer activity;
D O I：
10.1016/j.tetlet.2005.06.154
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
ZHD-0501, a novel naturally occurring staurosporine analog showing anticancer activity in vitro, was isolated from the fermentation broth of a marine-derived Actinomadura sp. 007 through a bioassay-guided separation procedure and its structure elucidated by spectroscopic methods. ZHD-0501 provided the first example of staurosporin analog carrying a heterocycle fused to the pyran ring adopting a boat conformation with C-2' and C-5' as the bow and stern, which inhibited the proliferation of mammalian cancer A549, BEL-7402, HL60, P388, and tsFT210 cells. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6137 / 6140
页数：4
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