Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives

被引：55

作者：

Nagarapu, Lingaiah ^{[1
]}

Mateti, Jhansi ^{[1
]}

Gaikwad, Hanmant K. ^{[1
]}

Bantu, Rajashaker ^{[1
]}

Rani, M. Sheeba ^{[1
]}

Subhashini, N. J. Prameela ^{[2
]}

机构：

[1] Indian Inst Chem Technol CSIR, Organ Chem Div 2, Hyderabad 500607, Andhra Pradesh, India

[2] Osmania Univ, Dept Pharm, Univ Coll Technol, Hyderabad 500607, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 14期

关键词：

Nonsterodial anti-inflammatory drugs; Pyrazole carboxamide derivative; Ibuprofen; Celecoxib; SELECTIVE INHIBITORS; COX-2; INHIBITORS; CYCLOOXYGENASE-2; POTENT; IDENTIFICATION; INFLAMMATION; CELECOXIB; PYRAZOLES; MECHANISM; ANALOGS;

D O I：

10.1016/j.bmcl.2011.05.105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4138 / 4140

页数：3

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