Clock Genes, Metabolism, and Cardiovascular Risk

被引:23
作者
Tarquini, Roberto [1 ,2 ]
Mazzoccoli, Gianluigi [3 ]
机构
[1] Univ Florence, Sch Med, Dept Clin & Expt Med, Viale Gaetano Pieraccini 6, I-50139 Florence, Italy
[2] Univ Florence, Sch Med, Interinst Dept Continu Care Empoli, Viale Gaetano Pieraccini 6, I-50139 Florence, Italy
[3] IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Chronobiol Unit, Div Internal Med, Cappuccini Ave, I-71013 Foggia, Italy
关键词
Clock; Gene; Circadian; Rhythm; Metabolism; Cardiovascular; REV-ERB-ALPHA; ACTIVATED PROTEIN-KINASE; MOUSE PERIPHERAL-TISSUES; FATTY LIVER-DISEASE; BILE-ACID SYNTHESIS; CIRCADIAN CLOCK; NUCLEAR RECEPTORS; GLUCOSE-HOMEOSTASIS; GUT MICROBIOTA; TRANSCRIPTIONAL REGULATION;
D O I
10.1016/j.hfc.2017.05.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The molecular clockwork drives rhythmic oscillations of signaling pathways managing intermediate metabolism; the circadian timing system synchronizes behavioral cycles and anabolic/catabolic processes with environmental cues, mainly represented by light/darkness alternation. Metabolic pathways, bile acid synthesis, and autophagic and immune/inflammatory processes are driven by the biological clock. Proper timing of hormone secretion, metabolism, bile acid turnover, autophagy, and inflammation with behavioral cycles is necessary to avoid dysmetabolism. Disruption of the biological clock and mistiming of body rhythmicity with respect to environmental cues provoke loss of internal synchronization and metabolic derangements, causing liver steatosis, obesity, metabolic syndrome, and diabetes mellitus.
引用
收藏
页码:645 / +
页数:12
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