Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling

被引：141

作者：

Packer, Lester ^{[1
]}

Cadenas, Enrique ^{[1
]}

机构：

[1] Univ So Calif, Sch Pharm, Los Angeles, CA 90089 USA

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2011年 / 48卷 / 01期

关键词：

lipoic acid; dihydrolipoic acid; energy; redox; AMPK; insulin; mitochondria; PGC1; alpha; ACTIVATED PROTEIN-KINASE; ACETYL-L-CARNITINE; ALPHA-KETOGLUTARATE DEHYDROGENASE; TRANSGENIC MOUSE MODELS; PYRUVATE-DEHYDROGENASE; INSULIN-RECEPTOR; SKELETAL-MUSCLE; GLUCOSE-TRANSPORT; HYDROGEN-PEROXIDE; CORTICAL-NEURONS;

D O I：

10.3164/jcbn.11-005FR

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The role of R-a-lipoic acid as a cofactor (lipoyllysine) in mitochondrial energy metabolism is well established. Lipoic acid non-covalently bound and exogenously administered to cells or supplemented in the diet is a potent modulator of the cell's redox status. The diversity of beneficial effects of lipoic acid in a variety of tissues can be mechanistically viewed in terms of thiol/disulfide exchange reactions that modulate the environment's redox and energy status. Lipoic acid-driven thiol/disulfide exchange reactions appear critical for the modulation of proteins involved in cell signaling and transcription factors. This review emphasizes the effects of lipoic acid on PI3K and AMPK signaling and related transcriptional pathways that are integrated by PGC-1 alpha, a critical regulator of energy homoestasis. The effects of lipoic acid on the neuronal energy-redox axis are largely reviewed in terms of their outcomes for aging and age-related neurodegenerative diseases.

引用

页码：26 / 32

页数：7

共 79 条

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