Induced neural stem cells as a means of treatment in Huntington's disease

被引：13

作者：

Choi, Kyung-Ah ^{[1
]}

Hong, Sunghoi ^{[1
,2
]}

机构：

[1] Korea Univ, Sch Biosyst & Biomed Sci, Coll Hlth Sci, 22Gil 6-3 Inchon Ro, Seoul 02855, South Korea

[2] Korea Univ, Dept Integrated Biomed & Life Sci, Coll Hlth Sci, Seoul, South Korea

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2017年 / 17卷 / 11期

关键词：

Induced neural stem cells; Huntington's diseases; stem cell therapy; cell conversion; MARROW STROMAL CELLS; ADULT HUMAN FIBROBLASTS; DIRECT CONVERSION; RAT MODEL; MOUSE FIBROBLASTS; PROGENITOR CELLS; NEURONAL CELLS; DOPAMINERGIC-NEURONS; FUNCTIONAL RECOVERY; MOLECULAR MEDICINE;

D O I：

10.1080/14712598.2017.1365133

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Introduction: Huntington's disease (HD) is an inherited neurodegenerative disease characterized by chorea, dementia, and depression caused by progressive nerve cell degeneration, which is triggered by expanded CAG repeats in the huntingtin (Htt) gene. Currently, there is no cure for this disease, nor is there an effective medicine available to delay or improve the physical, mental, and behavioral severities caused by it.Areas covered: In this review, the authors describe the use of induced neural stem cells (iNSCs) by direct conversion technology, which offers great advantages as a therapeutic cell type to treat HD.Expert opinion: Cell conversion of somatic cells into a desired stem cell type is one of the most promising treatments for HD because it could be facilitated for the generation of patient-specific neural stem cells. The induced pluripotent stem cells (iPSCs) have a powerful potential for differentiation into neurons, but they may cause teratoma formation due to an undifferentiated pluripotent stem cell after transplantation Therefore, direct conversion of somatic cells into iNSCs is a promising alternative technology in regenerative medicine and the iNSCs may be provided as a therapeutic cell source for Huntington's disease.

引用

页码：1333 / 1343

页数：11

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