The Protective Effect of Picroside II on Isoflurane-Induced Neuronal Injury in Rats via Downregulating miR-195

被引：0

作者：

Li, Hui ^{[1
]}

Yuan, Yawei ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Anesthesiol, Shanghai 200025, Peoples R China

[2] Shanghai First Matern & Infant Hosp, Dept Anesthesiol, Shanghai 300000, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2021年 / 40卷 / 09期

关键词：

isoflurane; microRNA-195; neuroinflammation; neuronal injury; picroside II; NEUROPATHIC PAIN; ISCHEMIA/REPERFUSION INJURY; SIGNALING PATHWAY; UP-REGULATION; NERVE INJURY; BRAIN; INHIBITION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We aimed to explore the protective effects of picroside II and the role of miR-195 on isoflurane-induced neuronal injury in rats. The results showed that picroside II significantly improves isoflurane-induced higher escape latency and lower time spent in quadrant compared with the control rats. Picroside II also promotes cell viability and suppresses cell apoptosis of isoflurane-induced neuronal cells. Besides, picroside II suppresses the expression of pro-inflammatory cytokines (IL-1 beta, IL-6, TNF-alpha) and miR-195 in vivo and in vitro. Furthermore, overexpression of miR-195 abrogates the effects of picroside II on the expression of pro-inflammatory cytokines. The appropriate dose of Picroside II is 20 mg/kg. Picroside II could protect the nervous system possibly through inhibiting the inflammatory response in the isoflurane-induced neuronal injury of rats. The protective effect of picroside II may be achieved by downregulating the expression of miR-195 and then inhibiting the inflammatory response.

引用

页码：2068 / 2076

页数：9

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