Organocatalytic and highly enantioselective direct α-amination of aromatic ketones

被引：132
作者：
Liu, Tian-Yu
Cui, Hai-Lei
Zhang, Yan
Jiang, Kun
Du, Wei
He, Zhao-Quan
Chen, Ying-Chun [1 ]
机构：
[1] Sichuan Univ, W China Sch Pharm, Minist Educ, Key Lab Drug Targeting, Chengdu 610041, Peoples R China
[2] Sichuan Univ, W China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China
[3] Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610064, Peoples R China
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 18期
关键词：
D O I：
10.1021/ol701648x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first highly enantioselective direct alpha-amination of aryl ketones was reported to be catalyzed by organic primary amines derived from cinchona alkaloids. Excellent enantioselectivities (88-99% ee) have been achieved for a broad spectrum of aryl ketones. The presence of 4 A molecular sieves was of great assistance for the high conversions and enantiocontrol.
引用
收藏
页码：3671 / 3674
页数：4
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