Chemical Strategies for Half-Life Extension of Biopharmaceuticals: Lipidation and Its Alternatives

被引：100

作者：

Bech, Esben M. ^{[1
,2
]}

Pedersen, Soren L. ^{[2
]}

Jensen, Knud J. ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Chem, DK-1871 Frederiksberg, Denmark

[2] Gubra Aps, DK-2970 Horsholm, Denmark

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2018年 / 9卷 / 07期

关键词：

ALBUMIN;

D O I：

10.1021/acsmedchemlett.8b00226

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Strategies for half-life extension are often required in the design of new biopharmaceuticals. This Viewpoint focuses on chemical moieties that convey protraction by albumin binding or by self-assembly to form larger structures, with GLP-1 and insulin as examples.

引用

页码：577 / 580

页数：7

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