Interaction of 4-Oxo-4H-pyrazolo[5,1-c][1,2,4]triazin-1-ides with Grignard Reagents

被引：10

作者：

Ivanov, Sergey M. ^{[1
]}

Shestopalov, Anatoliy M. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Leninsky Prospekt 47, Moscow 119991, Russia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 08期

关键词：

DERIVATIVES; REACTIVITY; PYRAZOLO; SYSTEM;

D O I：

10.1002/jhet.3236

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactions of magnesium 3-tert-butyl-8-R-4-oxo-4H-pyrazolo[5,1-c][1,2,4]triazin-1-ides (R=CN, CO2Et) with AlkMgBr led to nucleophilic additions to either side chain or triazine core, with selectivity being dependent on the nature of substituents, as well as on the solvents used. Previously inaccessible C-8-functionalized and C-4-functionalized pyrazolo[5,1-c][1,2,4]triazines and 3-tert-butyl-3-ethyl-4-oxo-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine were synthesized, and their reactivity and spectral data discussed.

引用

页码：1966 / 1972

页数：7

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