Silica Gel-mediated Synthesis of β-Enamino Esters and its Application for the Synthesis of Indeno 4-Hydroxypyridin-2(1H)-Ones

被引：4

作者：

Kim, Soong-Hyun ^{[1
]}

Bae, Seri ^{[1
]}

Ko, Eun Bi ^{[1
]}

Park, Ga Young ^{[1
]}

Lee, Eunhye ^{[1
]}

Hwang, Hee Jong ^{[1
]}

Im, Chun Young ^{[1
]}

Song, Minsoo ^{[1
]}

机构：

[1] DGMIF, NDDC, Dept Med Chem, Daegu 41061, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2019年 / 40卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

SiO2-based condensation; beta-keto ester; beta-enamino ester; 4-hydroxypyridine-2(1H)-one; SERIES;

D O I：

10.1002/bkcs.11676

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The full scope of SiO2-based condensation of aliphatic or aromatic amines and beta-keto esters to give beta-enamino esters was examined. Functionalized linear beta-enamino esters were easily obtained from SiO2-based condensation of beta-keto esters and amines only after simple filtration. It was also demonstrated that cyclic beta-enamino esters with 99% purity can be prepared in a practically large scale (60 g) without using silica gel column chromatography. The utility of the present method was fortified by the preparation of pharmaceutically useful indeno-4-hydroxypyridin-2(1H)-one analogue 11.

引用

页码：262 / 269

页数：8

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