THE EFFICIENT SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES AND THEIR SULFUR DERIVATIVES WITH H2SO4 IMMOBILIZED ON ACTIVATED CHARCOAL

被引：16

作者：

Dilmaghani, Karim Akbari ^{[1
]}

Zeynizadeh, Behzad ^{[1
]}

Parasajam, Hadi ^{[1
]}

机构：

[1] Urmia Univ, Dept Chem, Fac Sci, Orumiyeh, Iran

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2012年 / 187卷 / 04期

关键词：

3,4-Dihydropyrimidin-2(1H)-one; activated charcoal; H2SO4; Biginelli synthesis; ONE-POT SYNTHESIS; CATALYZED BIGINELLI REACTION; IMPROVED PROTOCOL CONDITIONS; CONDENSATION REACTION; CONVENIENT SYNTHESIS; RECYCLABLE CATALYST; SUPPORTED REAGENTS; REUSABLE CATALYST; ACID CATALYSIS; DIHYDROPYRIMIDINONES;

D O I：

10.1080/10426507.2011.631644

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Various 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) and their sulfur derivatives were efficiently synthesized by a one-pot cyclocondensation reaction of aromatic and aliphatic aldehydes, beta-dicarbonyl compounds and urea (or thiourea) in the presence of sulfuric acid immobilized on activated charcoal (133% w/w). The reactions were carried out in refluxing n-hexane-acetonitrile (2.5:0.5 mL) within 5-150 min to give 3,4-dihydropyrimidinones (or thiones) in high to excellent yields (81-97%).

引用

页码：544 / 553

页数：10

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