THE EFFICIENT SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES AND THEIR SULFUR DERIVATIVES WITH H2SO4 IMMOBILIZED ON ACTIVATED CHARCOAL

被引：16
|
作者：
Dilmaghani, Karim Akbari [1 ]
Zeynizadeh, Behzad [1 ]
Parasajam, Hadi [1 ]
机构：
[1] Urmia Univ, Dept Chem, Fac Sci, Orumiyeh, Iran
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2012年 / 187卷 / 04期
关键词：
3,4-Dihydropyrimidin-2(1H)-one; activated charcoal; H2SO4; Biginelli synthesis; ONE-POT SYNTHESIS; CATALYZED BIGINELLI REACTION; IMPROVED PROTOCOL CONDITIONS; CONDENSATION REACTION; CONVENIENT SYNTHESIS; RECYCLABLE CATALYST; SUPPORTED REAGENTS; REUSABLE CATALYST; ACID CATALYSIS; DIHYDROPYRIMIDINONES;
D O I：
10.1080/10426507.2011.631644
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Various 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) and their sulfur derivatives were efficiently synthesized by a one-pot cyclocondensation reaction of aromatic and aliphatic aldehydes, beta-dicarbonyl compounds and urea (or thiourea) in the presence of sulfuric acid immobilized on activated charcoal (133% w/w). The reactions were carried out in refluxing n-hexane-acetonitrile (2.5:0.5 mL) within 5-150 min to give 3,4-dihydropyrimidinones (or thiones) in high to excellent yields (81-97%).
引用
收藏
页码：544 / 553
页数：10
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