Structure-function relationships in nuclear receptors: the facts Response

被引:1
作者
Rastinejad, Fraydoon [1 ]
Ollendorff, Vincent [2 ]
Polikarpov, Igor [3 ]
机构
[1] Sanford Burnham Med Res Inst, Metab Dis Program, Lake Nona, FL 32827 USA
[2] Univ Montpellier I, INRA, Unite Mixte Rech Dynam Musculaire & Metabol 866, F-34000 Montpellier, France
[3] Univ Sao Paulo, IFSC, BR-13560970 Sao Carlos, SP, Brazil
关键词
RETINOIC ACID; DNA; COMPLEX; HETERODIMER; BINDING;
D O I
10.1016/j.tibs.2015.03.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We recently reviewed full-length nuclear receptor (NR) structures in an Opinion article wherein we carefully evaluated a large body of literature. As heads of three separate laboratories working on NR architectures, we expressed our shared insights and critical comments. One group (Moras et A) has declined to accept our strong concerns about several of their published reports. We comment on their letter.
引用
收藏
页码:290 / 292
页数:3
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