A novel antifouling alkaloid from halotolerant fungus Penicillium sp OUCMDZ-776

被引：25

作者：

He, Fei ^{[2
,3
,4
]}

Liu, Zhong ^{[5
]}

Yang, Jing ^{[6
]}

Fu, Peng ^{[1
]}

Peng, Jiang ^{[2
,3
,4
]}

Zhu, Wei-Ming ^{[1
]}

Qi, Shu-Hua ^{[2
,3
,4
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China

[3] Chinese Acad Sci, S China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangzhou 510301, Guangdong, Peoples R China

[4] Chinese Acad Sci, S China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China

[5] Jinan Univ, Natl Engn Res Ctr Genet Med, Guangdong Prov Key Lab Bioengn Med, Guangzhoujinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China

[6] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 18期

基金：

中国国家自然科学基金;

关键词：

Penicillium sp; Alkaloids; Antifouling;

D O I：

10.1016/j.tetlet.2012.02.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Penispirolloid A (1), a novel alkaloid possessing a unique Spiro imidazolidinyl skeleton, was isolated from a halotolerant fungal strain. Penicillium sp. OUCMDZ-776. Its structure was elucidated on the basis of spectroscopic methods and quantum chemical CD calculation. Compound 1 showed significant antifouling activity toward Bugula neritina larvae with EC50 of 2.40 mu g/ml. Plausible biogenesis of compound 1 was also proposed. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2280 / 2283

页数：4

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