Integrative genomic and transcriptomic analysis reveals immune subtypes and prognostic markers in ovarian clear cell carcinoma

被引：21

作者：

Ye, Shuang ^{[1
,2
]}

Li, Qin ^{[2
,3
,4
]}

Wu, Yutuan ^{[1
,2
]}

Jiang, Wei ^{[1
,2
]}

Zhou, Shuling ^{[2
,5
]}

Zhou, Xiaoyan ^{[2
,5
]}

Yang, Wentao ^{[2
,5
]}

Tu, Xiaoyu ^{[2
,5
]}

Shan, Boer ^{[1
,2
]}

Huang, Shenglin ^{[2
,3
,4
]}

Yang, Huijuan ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Canc Ctr, Dept Gynecol Oncol, Shanghai, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China

[3] Fudan Univ, Shanghai Canc Ctr, Shanghai, Peoples R China

[4] Fudan Univ, Inst Biomed Sci, Shanghai Key Lab Med Epigenet, Shanghai, Peoples R China

[5] Fudan Univ, Shanghai Canc Ctr, Dept Pathol, Shanghai, Peoples R China

来源：

BRITISH JOURNAL OF CANCER | 2022年 / 126卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CANCER; IDENTIFICATION; BIOMARKERS; MUTATIONS; DISCOVERY; THERAPY; PROGRAM;

D O I：

10.1038/s41416-022-01705-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background We performed an integrative genomic and transcriptomic profiling to identify molecular subtypes and prognostic markers with special focus on immune-related pathways. Methods Totally, 50 Chinese patients were subjected to targeted next-generation sequencing and transcriptomic sequencing. Results Two distinct subgroups were identified as immune (22.0%) and non-immune (78.0%) based on the immune-pathway related hierarchical clustering. Surprisingly, patients with immune subtype had a significantly worse survival. The prognostic capacity was validated in external cohorts. The immune group had higher expression of genes involved in pro-inflammation and checkpoints. PD-1 signalling pathway was enriched in the immune subtype. Besides, the immune cluster presented enriched expression of genes involved in epithelial-mesenchymal transition, angiogenesis and PI3K-AKT-mTOR signalling, while the non-immune subtype had higher expression of metabolic pathways. The immune subtype had a higher mutation rate of PIK3CA though significance was not achieved. Lastly, we established a prognostic immune signature for overall survival. Interestingly, the immune signature could also be applied to renal clear cell carcinoma, but not to other histologic subtype of ovarian cancer. Conclusions An immune subtype of OCCC was identified with poor survival and enrichment of PD-1 and PI3K-AKT-mTOR signalling. We constructed and validated a robust prognostic immune signature of OCCC patients.

引用

页码：1215 / 1223

页数：9

共 49 条

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