Recent advances in biotechnological production of 2-phenylethanol

被引：213

作者：

Hua, Dongliang ^{[1
,2
,3
,4
]}

Xu, Ping ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China

[3] Shandong Acad Sci, Energy Res Inst, Key Lab Biomass Gasificat Technol Shandong Prov, Jinan 250014, Peoples R China

[4] Apple Flavor & Fragrance Grp Co Ltd, Shanghai 201809, Peoples R China

来源：

BIOTECHNOLOGY ADVANCES | 2011年 / 29卷 / 06期

基金：

中国博士后科学基金;

关键词：

2-phenylethanol; L-phenylalanine; Ehrlich pathway; Biotransformation; In situ product removal; AROMA COMPOUND 2-PHENYLETHANOL; PICHIA-FERMENTANS L-5; L-PHENYLALANINE; SACCHAROMYCES-CEREVISIAE; BIOCATALYTIC SYNTHESIS; BACILLUS-PUMILUS; BIOCONVERSION; BIOTRANSFORMATION; SOLVENT; 2-PHENYLETHYLACETATE;

D O I：

10.1016/j.biotechadv.2011.05.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries and is mainly produced by chemical synthesis. An alternative method for the production of natural flavors and fragrances is the microbial transformation process, which is attracting increasing attention because it is an environmentally friendly process and the products are considered "natural". The production of 2-PE from L-phenylalanine by biotransformation is possible through the Ehrlich pathway and considerable progress has been made in the development of this process. The present report reviews recent advances in biotechnological production of 2-PE, with emphasis on the strategies used to increase production and the applications of in situ product removal techniques. Future research should focus on product scale-up and product recovery processes for the industrialization of microbial processes. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：654 / 660

页数：7

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