Cytological Diagnosis of Sarcoidosis Revisited: A State of the Art Review

Diagnosis of sarcoidosis has never been an easy task. This is primarily because there is no single diagnostic test that can clinch the diagnosis. Demonstration of granulomas remains an essential criteria, but as granulomatous inflammation can be seen in host of conditions, it is necessary to exclude all possible causes, as well as to correlate with other findings, before arriving at the diagnosis of sarcoidosis. Cytology has been used effectively since the last few decades in demonstration of granulomas in various organs. Recent developments in various fields of cytodiagnosis of sarcoidosis including transesophageal ultrasound-guided fine-needle aspiration and endobronchial ultrasonograpy-guided transbronchial needle aspiration have revolutionized this field. These techniques are safe, minimally invasive, and give real-time information during aspiration. In comparision to the conventional methods, these allow easier sampling and have better sensitivity. In addition to these methods, a variety of ancillary techniques are also utilized and are reviewed here. Diagn. Cytopathol. 2011; 39: 541-548. (C) 2010 Wiley-Liss, Inc.