Increased IL-13-producing T cells in ALS: Positive correlations with disease severity and progression rate

被引：58

作者：

Shi, Nan ^{[1
]}

Kawano, Yuji ^{[1
]}

Tateishi, Takahisa ^{[1
]}

Kikuchi, Hitoshi ^{[1
]}

Osoegawa, Manabu ^{[1
]}

Ohyagi, Yasurnasa ^{[1
]}

Kira, Jun-ichi ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Inst Neurol, Dept Neurol, Fukuoka 812, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 182卷 / 1-2期

关键词：

amyotrophic lateral sclerosis; interleukin-13; neuroinflammation; CD4(+) T cell; CD8(+) T cell;

D O I：

10.1016/j.jneuroim.2006.10.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We measured the intracellular productions of IFN gamma, IL-2, IL-4, IL-13 and TNF alpha in peripheral blood CD4(+) and CD8(+) T cells from 21 amyotrophic lateral sclerosis (ALS) patients, 14 disease controls (DC) with spinocerebellar degeneration and 16 healthy controls (HC). Only the percentages of CD4(+)IL-13(+) and CD8(+)IL-13(+) T cells were significantly higher in ALS patients than in DC and HC. The CD4(+)IL-13(+) T cell percentages showed a significant negative correlation with the revised ALS functional rating scale scores and significant positive correlation with the disease progression rate, suggesting that IL-13 contributes to ALS. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：232 / 235

页数：4

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