Synthesis and characterisation of some novel fused thiazolo[3,2-a] pyrimidinones and pyrimido[2,1-b][1,3]thiazinones

被引：11
作者：
Abbas, Ikhlass M. [1 ]
Gomha, Sobhi M. [1 ]
Elaasser, Mahmoud M. [2 ]
Mabrouk, Bazada K. A. [1 ]
机构：
[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt
[2] Al Azhar Univ, Reg Ctr Mycol & Biotechnol, Cairo, Egypt
来源：
JOURNAL OF CHEMICAL RESEARCH | 2015年 / 12期
关键词：
thiazolo[3,2-a]pyrimidinones; pyrimido[2,1-b][1,3]thiazinones; thiones; cytotoxic activity; ANTICANCER ACTIVITY; DERIVATIVES; HETEROCYCLES; THIAZOLOPYRIMIDINE; ANTITUMOR; BEARING; ANTIOXIDANT; MOIETIES;
D O I：
10.3184/174751915X14474391581067
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reactions of 7,9-bis(4-methoxyphenyl)-2-thioxo-2,3-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one with alpha-haloketones, chloroacetonitrile and DMAD, afforded the corresponding fused thiazolo[3,2-a]pyrimidinone derivatives. The reaction of the thione with chloroacetic acid and an appropriate aromatic aldehyde yielded the respective 2-arylidene-2H-pyrido[3',2':4,5]thieno[3,2-d]thiazolo[3,2-a]pyrimidine-3,5-diones. Also, the treatment of thione with arylidenemalononitriles gave the fused pyrimido[2,1-b][1,3]thiazine derivatives, respectively. The structures of the synthesised products were confirmed by IR, H-1 NMR and mass spectral techniques. The cytotoxic activity of the new products against breast carcinoma (MCF-7) and hepatocellular carcinoma (HepG2) cell lines were determined and the results revealed promising activity.
引用
收藏
页码：719 / 723
页数：5
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