Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged

被引：40
作者：
Vallejo, Abbe N.
机构：
[1] Pittsburgh Rangos Res Ctr, Childrens Hosp, Div Rheumatol, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15261 USA
[4] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15260 USA
[5] McGowan Inst Regenerat Med, Pittsburgh, PA 15213 USA
来源：
IMMUNOLOGIC RESEARCH | 2006年 / 36卷 / 1-3期
关键词：
aging; replicative senescence; T cell repertoire; telomere;
D O I：
10.1385/IR:36:1:221
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aging immune system is characterized by the contraction of T Cell receptor (TCR) diversity and the de novo expression of NK-related receptors (NKR) on oligoclonal T cells. NKR+ T cells likely represent a secondary immune diversification as a biological adaptation of aging to ensure host defense despite shrinkage of the TCR repertoire. NKRs are expressed in various combinations even among TCR-identical cells, and are capable of triggering effector pathways in either TCR-independent or TCR-dependent fashion. Understanding the biology of NKR+ T cells will be pivotal to the development of strategies to enhance immunity in the elderly.
引用
收藏
页码：221 / 228
页数：8
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